Gil Alterovitz

Gil Alterovitz教授,哈佛大学医学院生物信息学控制实验室主任。

主要研究领域:生物信息学,贝叶斯网络模型,数据挖掘,移动健康,健康信息系统

主页http://bcl.med.harvard.edu/people/gil/

 

工作经历:

  • 2011–至今:助理教授 哈佛医学院 哈佛大学
  • 2010–2010:客座讲师 电子工程与计算机科学系 麻省理工学院
  • 2009–2010:讲师 哈佛医学院 哈佛大学
  • 2009–至今:职员科学家 哈佛大学/麻省理工学院健康科学与技术部门   波士顿儿童医院
  • 2007–2009:兼任助理教授 计算机与信息系 东北大学
  • 2006–2009: 研究员 哈佛大学/麻省理工学院健康科学与技术部门   波士顿儿童医院
  • 2006–至今:研究员 电子工程与计算机科学系 麻省理工学院

近五年出版的著作及发表的重要论文:

  • 著作:
  1. Alterovitz G, Ramoni MF: Knowledge-Based Bioinformatics: From Analysis to Interpretation. London/New York: John Wiley & Sons; 2010.
  2. Alterovitz G, Benson R, Ramoni MF (eds.): Automation in Proteomics and Genomics: An Engineering Case-Based Approach. London/New York: John Wiley & Sons; 2009.
  3. Alterovitz G, Ramoni MF: Systems Bioinformatics: An Engineering-Based Problem Solving Approach. Artech House, 2007.
  4. Wood C, Alterovitz G: Fundamentals of Design for Synthetic Biology. In: Systems Bioinformatics: An Engineering Case-Based Approach. Edited by Alterovitz G, Ramoni MF. New York: Artech House; 2007.
  5. Muralidhar V, Szabo G, Alterovitz G: Topological Analysis of Biomolecular Networks. In: Systems Bioinformatics: An Engineering Case-Based Approach. Edited by Alterovitz G, Ramoni MF. New York: Artech House; 2007.
  • 论文:
  1. Alterovitz G, Xiang M, Hill DP, Lomax J, Liu J, Cherkassky M, Dreyfuss J, Mungall C, Harris MA, Dolan ME et al, “Ontology engineering”, Nature Biotechnology 2010, 28(2):128-130. (2011年影响因子23.268)
  2. Quo C, Kaddi C, Phan J, Zollanvari A, Wang M, Alterovitz G, “Reverse engineering bio-molecular systems (REBMS) using -omic data: challenges, progress, and opportunities”, Brief Bioinform 2012 (In Press). (2011年影响因子5.202)
  3. Warner J, Alterovitz G, “Phenome-based analysis as a means for discovering context-dependent clinical reference ranges”,  AMIA Annu Symp Proc 2012 (Accepted).
  4. Parikh N, Zollanvari A, Alterovitz G, “An automated Bayesian framework for integrative gene expression analysis and predictive medicine”, AMIA Summits Transl Sci Proc 2012, 2012:95-104.
  5. Marwah K, Katzin D, Zollanvari A, Noy NF, Ramoni M, Alterovitz G, “Context-specific ontology integration: a Bayesian approach”, AMIA Summits Transl Sci Proc 2012, 2012:79-86.
  6. Deng M, Zollanvari A, Alterovitz G, “A Bayesian translational framework for knowledge propagation, discovery, and integration under specific contexts”, AMIA Summits Transl Sci Proc 2012, 2012:25-34.
  7. Marwah K, Zollanvari A, Alterovitz G, “Hyper-experiments: Bayesian inference and annotation for GEO”, Proceeding of American Medical Informatics Association Translational Bioinformatics (AMIA TBI) 2012.
  8. Zollanvari A, Alterovitz G, “Prediction-based Bayesian network analysis of gene sets for genome-wide association and expression studies”, Proceeding of American Medical Informatics Association Translational Bioinformatics (AMIA TBI) 2012.
  9. Wu A, Zollanvari A, Alterovitz G, “Multinet Bayesian networks for integrative genomic discovery: application to genetic epistatic interactions in HIV”, Presented in American Medical Informatics Association Translational Bioinformatics (AMIA TBI) 2012.
  10. Zollanvari A, Thomas J, Alterovitz G, “A prediction-based Bayesian framework for quantifying the interaction of demographics and genetics: application to alcohol dependence”, Presented in American Medical Informatics Association Translational Bioinformatics (AMIA TBI) 2012.
  11. Ting C, Alterovitz G, Merlob A, Abdi R, “Genomic studies of GVHD-lessons learned thus far”, Bone Marrow Transplant 2012. (2011年影响因子3.746)
  12. Zollanvari A, Deng M, Alterovitz G, “A context specific Bayesian framework for knowledge propagation and discovery”, Proceeding of Progress in Biomedical Science and Engineering 2011.
  13. Zollanvari A, Saccone NL, Bierut LJ, Ramoni MF, Alterovitz G, “Is the reduction of dimensionality to a small number of features always necessary in constructing predictive models for analysis of complex diseases or behaviours?”, Conf Proc IEEE Eng Med Biol Soc 2011, 2011:3573-3576.
  14. Alterovitz G, Tuthill C, Rios I, Modelska K, Sonis S, “Personalized medicine for mucositis: Bayesian networks identify unique gene clusters which predict the response to gamma-D-glutamyl-L-tryptophan (SCV-07) for the attenuation of chemoradiation-induced oral mucositis”, Oral Oncol 2011, 47(10):951-955. (2011年影响因子2.857)
  15. Alterovitz G, Cavalcanti S, Muso TM, Ramoni MF, Wang M, “Reverse engineering and synthesis of biomolecular systems”, Pac Symp Biocomput 2011:300-301.
  16. Hartwig S, Ho J, Pandey P, Macisaac K, Taglienti M, Xiang M, Alterovitz G, Ramoni M, Fraenkel E, Kreidberg JA, “Genomic characterization of Wilms’ tumor suppressor 1 targets in nephron progenitor cells during kidney development”, Development 2010, 137(7):1189-1203. (2011年影响因子6.596)
  17. Chang HH, McGeachie M, Alterovitz G, Ramoni MF, “Mapping transcription mechanisms from multimodal genomic data”, BMC Bioinformatics 2010, 11 Suppl 9:S2. (2011年影响因子2.751)
  18. Alterovitz G, Muso T, Ramoni MF, “The challenges of informatics in synthetic biology: from biomolecular networks to artificial organisms”, Brief Bioinform 2010, 11(1):80-95. (2011年影响因子5.202)
  19. Alterovitz G, Cavalcanti S, Muso TM, Ramoni MF, Wang M, “Reverse engineering and synthesis of biomolecular systems”, Pac Symp Biocomput 2010:383-384.
  20. Maron JL, Alterovitz G, Ramoni M, Johnson KL, Bianchi DW, “High-throughput discovery and characterization of fetal protein trafficking in the blood of pregnant women”, Proteom Clin Appl 2009, 3(12):1389-1396. (2011年影响因子1.97)
  21. Celi LA, Hinske LC, Alterovitz G, Szolovits P, “An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study”, Crit Care 2008, 12(6):R151. (2011年影响因子4.607)
  22. Alterovitz G, Xiang M, Liu J, Chang A, Ramoni MF, “System-wide peripheral biomarker discovery using information theory”, Pac Symp Biocomput 2008:231-242.
  23. Alterovitz G, Jiwaji A, Ramoni MF, “Automated programming for bioinformatics algorithm deployment”, Bioinformatics 2008, 24(3):450-451. (2011年影响因子5.468)
  24. Alterovitz G, Xiang M, Liu J, Chang A, Ramoni MF, “Discovering biofluid biomarkers using an information theoretic proteomics framework”, Proceedings of the Pacific Symposium on Biocomputing, 2008.
  25. Maron JL, Johnson KL, Slonim D, Lai CQ, Ramoni M, Alterovitz G, Jarrah Z, Yang Z, Bianchi DW, “Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood”, J Clin Invest 2007, 117(10):3007-3019. (2011年影响因子13.069)
  26. Alterovitz G, Xiang M, Mohan M, Ramoni MF, “GO PaD: the Gene ontology partition database”, Nucleic Acids Res 2007, 35(Database issue):D322-327.(2011年影响因子8.026)
  27. Alterovitz G, Muso T, Malalur P, Ramoni MF, “A systematic approach to quantifying evolutionary functional trends across the universal tree of life”, Proceedings of the IEEE 7th International Symposium on Bioinformatics and Bioengineering (BIBE) 2007:374-378.
  28. Alterovitz G, Lyashenko E, Xiang M, Ramoni MF, “Linking protein mass with function via organismal massome networks”, Proceedings of the IEEE 7th International Symposium on Bioinformatics and Bioengineering (BIBE) 2007:59-65.
  29. Alterovitz G, Liu J, Afkhami E, Ramoni MF, “Bayesian methods for proteomics”, Proteomics 2007, 7(16):2843-2855. (2011年影响因子4.505)
  30. Alterovitz G, Xiang M, Kohane IS, and Ramoni MF, “Mass similarity shapes protein interaction networks and is conserved across evolution”, PLoS ONE, 2007. (2011年影响因子4.092)
  31. Alterovitz G, Ramoni MF, “Bioinformatics and Proteomics: An Engineering-Based Problem Solving Approach”, IEEE Transactions on Education, 2007, vol.50, pp.49-54. (2011年影因子1.021)

 

主持、参与的重点科研项目:

  • 美国国立卫生研究院项目:一种用于生物医学网络信息处理的全局方法(NIH-NLM, R00LM009826, 2010-2013)
  • 美国国立卫生研究院项目:生物医学知识的自动整合(NIH-NHGRI,R01HG004836, 2010-2013)
  • 美国国立卫生研究院项目:不止是关联:尼古丁预测建模(NIH-NIDA,R21DA025186, 2010-2013)
  • 中国国家自然科学基金:结合多疾病分析刻画孤独症基因系统(NSFC,R01MH090611-S, 2012-2013)
  • 美国国立卫生研究院项目:结合多疾病分析刻画孤独症基因系统(NIH-NIMH, R01MH090611-S, 2012-2013)
  • 美国国家协调局项目:SMART基因组报告(subproject under SMART Grant, 2012-2013)
  • 美国国立卫生研究院项目:一种用于生物医学信息处理的全局方法(NIH-NLM, K99LM009826, 2008-2010)
  • 美国国家卫生研究院项目:波士顿地区生物医疗信息学方面的研究训练项目(NIH-NLM, 2-T15-LM007092-16, 2006-2008)

 

学术成果与奖励:

  • 论文《Ontology engineering》发表在Nature Biotechnology,2010年
  • 美国医学信息学协会(AMIA),学生竞赛奖,第一名,2006年
  • 美国国立卫生研究院,医学医疗信息学学术奖金,2006年
  • 美国医学信息学协会(AMIA),马丁·爱泼斯坦奖,2006年

 

 

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